ENdb 2.0: an updated database of experimentally supported enhancers.

ENdb 2.0 is an updated manually curated database of experimentally supported enhancers, expanding literature coverage through 2026 and adding 4831 enhancer evidence records across five species.

• Why it matters: Enhancer candidates from genome-wide mapping are abundant, but experimentally supported enhancer details are scattered across studies and experimental systems, limiting reuse and cross-condition analysis.
• What they did: The team curated ENdb 2.0 with 4831 enhancer evidence records, including 2793 enhancer–TF–target gene records spanning 496 TFs and 1070 target genes, plus enriched annotations for conditions, tissues, and diseases.
• The result: ENdb 2.0 links enhancer regions to regulatory factors, target genes, and supporting experiments across physiological and disease states, enabling biological search, genome browsing, pathway enrichment, and structured downloads.

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