DiseaseCIO: a multi-omics atlas for characterizing clinical intervention outcomes across diverse diseases.

DiseaseCIO integrates 42 798 pretreatment samples across 94 disease states and 510 treatment regimens, linking multi-omics profiles to >1.84 million candidate feature–outcome associations.

• Why it matters: Patient-to-patient variability in clinical intervention outcomes limits precision medicine, and multi-omics integration is needed to uncover molecular patterns tied to response, prognosis, and resistance.
• What they did: The database combines microbiome, transcriptome, and epigenome data with intervention outcomes, processed via a customized iMOD workflow to generate 20 molecular feature categories.
• The result: DiseaseCIO enables differential analysis, prognostic evaluation, cross-omics correlation, and enrichment/signature construction to explore outcome heterogeneity and identify candidate multi-omics biomarkers.

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