Nucleic Acids ResJClub
4D-atlas: a multi-species four-dimensional spatiotemporal transcriptomics database spanning development, regeneration, and disease.
Nucleic Acids Research · · Journal Article · Open access
Zhao, Liu + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
4D-atlas is the first publicly accessible multi-species 4D spatial transcriptomics database, standardizing 1629 spatial slices across 88 time points and 22.2 million cells.
- Why it matters: Dynamic processes in development, regeneration, and disease require molecular landscapes mapped across both 3D tissue structure and time, but no public multi-species 4D atlas existed.
- What they did: The database compiles 15 datasets across six species, covering 2–41 slices per dataset, and provides seven interactive modules for 4D exploration and unified integration across stages.
- The result: With standardized data and a unified analytical pipeline, 4D-atlas enables systematic investigation of tissue morphogenesis and dynamic regulatory programs across time and space.
The findingWhy it mattersWhat they didThe result
- Open access