Nucleic Acids ResJClub
scSpatial: an atlas for single-cell spatial omics.
Nucleic Acids Research · · Journal Article · Open access
Sun, Bei + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
scSpatial provides an expert-curated atlas for single-cell spatial omics, covering over 1800 tissue sections and >20 million spatially resolved cells across 16 spatial technologies.
- Why it matters: Single-cell spatial omics datasets are fragmented across publications, and comprehensive, standardized resources with high-resolution spatial mappings are still lacking.
- What they did: The atlas integrates spatial coordinates with molecular profiles and cell identities, curating data from 630 projects and annotating cells into 173 standardized Cell Ontology types.
- The result: It enables SCSO-tailored analyses and interactive visualizations, including spatial gene expression atlases, cell type distribution maps, spatially variable genes, gene expression correlations, and pathway-level spatial activity profiles.
The findingWhy it mattersWhat they didThe result
- Open access