Oral KCl Supplementation Safely Reduces Body Na(+) Surplus and Blood Pressure.

Oral potassium chloride (KCl) supplementation for 6–9 weeks eliminated the muscle Na+ surplus in hyperaldosteronism, with a -1.90 mmol/L tissue volume reduction.

• Why it matters: It addresses whether potassium-enriched salt benefits blood pressure by reducing body sodium stores and correcting Na+/K+ imbalance, not just by changing salt intake.
• What they did: In a single-arm prospective study of 40 adults with hypertension, participants received personalized blood K+-adjusted KCl (600 mg) for 6–9 weeks, then underwent classification as essential hypertension or hyperaldosteronism.
• The result: KCl increased 24-hour urine K+ without changing 24-hour urine Na+, lowered blood Na+/K+ ratios in both groups, and reduced systolic blood pressure by 8.33 mm Hg (EH) and 7.35 mm Hg (hyperaldosteronism).

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