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Intensive Blood-Pressure Control in Patients with Previous Ischemic Stroke.
New England Journal of Medicine · · Journal Article
Sampaio Silva, Machline-Carrion + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Targeting systolic blood pressure <120 mm Hg after prior ischemic stroke or transient ischemic attack reduced major cardiovascular events versus <140 mm Hg (HR 0.79).
- Why it matters: It was uncertain whether intensive blood-pressure lowering after cerebrovascular events lowers cardiovascular risk, leaving clinicians without clear guidance for secondary prevention.
- What they did: In a multicenter open-label randomized trial in Brazil (30 sites), 4368 participants were assigned to intensive treatment (<120 mm Hg) or standard treatment (<140 mm Hg) and followed for a median of 3.9 years.
- The result: Excluding the first 3 months, mean systolic pressure was 122.0±11.5 vs 135.2±9.7 mm Hg, and the primary composite occurred in 10.9% vs 13.5% (P=0.007), with similar serious adverse events.
The findingWhy it mattersWhat they didThe result
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