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Intensive Blood-Pressure Lowering in Patients with Type 2 Diabetes.
New England Journal of Medicine · · Journal Article
Santo, Martins + more
Abstract ↗AI summary
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Targeting systolic blood pressure <120 mm Hg versus <140 mm Hg in 9476 patients with type 2 diabetes did not reduce major cardiovascular events over 4.0 years.
- Why it matters: Evidence has been uncertain about whether intensive blood-pressure lowering improves cardiovascular outcomes in people with type 2 diabetes at high cardiovascular risk.
- What they did: In a multicenter, open-label randomized trial in Brazil, patients were assigned to intensive therapy (<120 mm Hg) or standard therapy (<140 mm Hg), with follow-up for a composite cardiovascular endpoint.
- The result: Primary events occurred in 6.0% (286/4745) with intensive therapy versus 6.7% (315/4731) with standard therapy (hazard ratio 0.90; 95% CI 0.77–1.06; P=0.20), with similar serious adverse event rates.
The findingWhy it mattersWhat they didThe result
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