Sex-specific biological aging clocks across organs and omics.

Sex-specific biological aging clocks across organs reveal distinct genetic, molecular, and clinical aging signatures in males and females.

• Why it matters: Understanding sex differences in aging is crucial because most existing models assume sex invariance, potentially obscuring important biological and clinical distinctions that could improve personalized health strategies.
• What they did: Developed 38 sex-specific aging clocks across 15 organ systems using sex-stratified training, genetic analyses, proteomics, and longitudinal survival data to compare male and female aging patterns.
• The result: Findings demonstrate that sex-specific clocks better predict diseases and mortality, uncover sex-dependent molecular networks, and emphasize the importance of sex-stratified models for accurate aging and disease assessment.