In vivo porcine multi-omics integration identifies microbiome-driven histamine elevation and lasting gut perturbations following Ascaris suum infection and fenbendazole treatment.

Infection and fenbendazole treatment cause lasting gut microbiome changes and elevated histamine levels in pigs infected with Ascaris suum, even after worm clearance.

• Why it matters: Understanding how anthelmintic treatments impact the gut microbiome and host metabolism is crucial for improving parasite management and minimizing long-term gut disturbances.
• What they did: The study used integrated multi-omics analysis and in vitro experiments to examine microbial and metabolic alterations in infected pigs, identifying persistent changes 13 days post-treatment.
• The result: Findings reveal that infection and treatment induce durable microbiome shifts and increased histamine production, highlighting complex host-microbiota-parasite interactions that influence gut health and treatment outcomes.