LPL-Positive Endothelial Cells Control T-cell Homing in Liver Metastasis.

LPL-positive endothelial cells promote intratumoral CD8+ T-cell homing and liver metastasis regression by enhancing antigen presentation.

• Why it matters: Understanding how to activate effective T-cell responses in immunologically cold tumors is crucial for improving immunotherapy outcomes, especially where tumors have low MHC-I expression.
• What they did: The study traced transcriptional responses of liver metastasis-associated endothelial cells, identifying a subpopulation expressing lipoprotein lipase (LPL) that facilitates T-cell infiltration through MHC-I-dependent cross-presentation.
• The result: Presence of LPL+ blood vessels correlates with T-cell accumulation in human liver metastasis samples, suggesting that targeting TECs to boost antigen presentation could enhance immunotherapy efficacy.