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Gut Pathobionts Translocate into the Liver and Reshape Intrahepatic Microbiome to Facilitate Hepatocellular Carcinoma.
Cancer Discovery · · Journal Article · Open access
Liu, Wang + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
In HCC patients, gut pathobionts show increased gut–liver microbiome similarity and a gut pathobionts–centered network, indicating microbial transfer via the gut–liver axis.
- Why it matters: The intrahepatic microbiome’s role in hepatocellular carcinoma is unclear, limiting understanding of how gut microbes might reach the liver and influence tumor biology.
- What they did: Matched gut and intrahepatic microbiomes were profiled in HCC patients and healthy subjects, and HCC stool transplantation into germ-free mice was used to test gut barrier and liver bacterial load.
- The result: Gut pathobionts in tumor regions correlate with host cytokine expression and oncogenic pathways, and Bacteroides fragilis (including its surface protein Enolase) promotes liver damage and HCC development in mice.
The findingWhy it mattersWhat they didThe result
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