Galvanin (TMEM154) is an electric-field sensor for directed cell migration.

Cell · 25 June 2026 · Journal Article · Open access

Belliveau, Footer + more

The abstract is read at the publisher; the summary is JClub's.

Galvanin (TMEM154) is required for electric-field-guided migration of rapidly moving cells, and its expression is sufficient to confer this responsiveness in epithelial cells.

Why it matters: Directed migration toward wound sites depends on endogenous electric fields, but the mechanism by which single cells detect and translate these electrical cues was unclear.
What they did: The study identified Galvanin (TMEM154) as required for electric-field-guided migration, then showed expression is sufficient in otherwise non-responsive epithelial cells; upon exposure, Galvanin relocalizes to the anodal side.
The result: In human neutrophils, Galvanin relocalization is immediately followed by changes in spatial patterns of protrusion and retraction, supporting Galvanin as a direct electric-field sensor that informs the migratory apparatus.

AI summary of the abstract · may contain errors · not medical advice · read the paper.

Open access
3 cites

Free. We’ll email you when a new paper cites this one or any other paper you follow on JClub — at most one email a day. Every email has a one-tap unsubscribe.

Biomechanical Compartmentalisation Influences Angiogenesis and Stem Cell Proliferation in the Regenerating Intestine via Vascular Piezo.
bioRxiv · 5 Nov 2026 · Preprint
AI summary · may contain errors
Piezo mechanosensing in the regenerating Drosophila melanogaster midgut tracheal system is linked to Yorkie/YAP activation, driving tracheal remodeling and intestinal stem cell proliferation.
- Open access
Open
Share
Post on X Post on Bluesky Share on LinkedIn
https://jclub.com.au/a/10.1101/2025.04.16.649133
Open in JClub
Spiny mouse fibroblasts exhibit a baseline preference for glycolysis and are resilient to oxidative stress across lifespan
bioRxiv · 4 Nov 2026 · Preprint
AI summary · may contain errors
Primary ear pinna fibroblasts from spiny mice show a baseline glycolysis preference linked to lower ROS production and remain highly resistant to oxidative stress across lifespan.
- Open access
- 1 cites
Open
Share
Post on X Post on Bluesky Share on LinkedIn
https://jclub.com.au/a/10.1101/2025.10.02.680123
Open in JClub
Dynamic control of cell state transitions during tissue morphogenesis.
EMBO Journal · 1 Nov 2026 · Review
AI summary · may contain errors
Cell state transitions during tissue morphogenesis are coordinated by dynamic interplay among gene expression programs, chromatin modifications, and microenvironment biophysical factors.
- Open access
Open
Share
Post on X Post on Bluesky Share on LinkedIn
https://jclub.com.au/a/42697964
Open in JClub

Journals this month

All journals →

Topics moving, week to 13 Nov 2026

All topics →

By field

All journals by field →

Galvanin (TMEM154) is an electric-field sensor for directed cell migration.

Related in JClub

Biomechanical Compartmentalisation Influences Angiogenesis and Stem Cell Proliferation in the Regenerating Intestine via Vascular Piezo.

Spiny mouse fibroblasts exhibit a baseline preference for glycolysis and are resilient to oxidative stress across lifespan

Dynamic control of cell state transitions during tissue morphogenesis.

Browse JClub