Mismatch Repair-Proficient Colorectal Cancer Can Evade Immune Surveillance through an Intrinsic Suppressive Program.
- Open access
Mismatch repair-proficient Colorectal Cancer evades immune attack through intrinsic secretome-driven suppression, despite identical antigen presentation in 25 words.
- Why it matters: Understanding immune evasion mechanisms beyond neoantigen load is crucial because MSS-CRC tumors resist immunotherapy even with similar antigen levels, limiting treatment options.
- What they did: Researchers engineered models with equal antigen expression in MSI- and MSS-CRC cells, then analyzed immune responses, secretome effects, and surface glycosylation via mass spectrometry.
- The result: MSS-CRC suppresses T-cell activation and cytotoxicity through glycosylation-dependent secretome alterations, suggesting targeting these pathways could enhance immunotherapy effectiveness.