Nuclear speckles enable processing of RNA from GC-rich isochores.

Cell · 2 Apr 2026 · Journal Article · Open access

Małszycki, Martina + more

The abstract is read at the publisher; the summary is JClub's.

Acute removal of SON and SRRM2 in human cells significantly downregulates GC-rich genes with short introns within GC-rich isochores due to inefficient, chaotic splicing.

Why it matters: Speckles are linked to post-transcriptional processing, but their specific role in handling GC-rich isochores and splicing by-products was unclear.
What they did: Engineered, acute depletion of SON and SRRM2 speckle core components with intrinsically disordered regions was used, followed by expression and splicing analyses across isochores.
The result: Genes outside GC-rich isochores remain unaffected, and cross-eukaryote comparisons show GC-rich isochores and speckles occur exclusively in amniotes, with SON IDRs expanded there.

AI summary of the abstract · may contain errors · not medical advice · read the paper.

Open access
9 cites

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Genome Research · 11 Nov 2026 · Journal Article
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Nuclear speckles enable processing of RNA from GC-rich isochores.

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Kinase-phosphatase cycles drive self-sustained oscillations of protein condensates

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