The abstract is read at the publisher; the summary is JClub's.
HIV-1 ASP interacts with nuclear, cytosolic, and mitochondrial host factors, and ASP shuttles to the nucleus to promote DNA damage repair and cell viability under genotoxic stress.
- Why it matters: The viral asp gene is conserved and expressed in vivo, but ASP’s function is unclear; defining its host interactions is key to understanding HIV-1 persistence and reservoir survival.
- What they did: The team used an MS-based proteomics screen to identify ASP interactors, then validated function by testing ASP’s nuclear shuttling and effects on DNA damage repair and cell viability during genotoxic stress.
- The result: ASP also promotes translation of mitochondrially encoded host proteins tied to cellular respiration and helps maintain mitochondrial membrane potential, linking ASP to DNA repair and mitochondrial homeostasis.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.