The abstract is read at the publisher; the summary is JClub's.
In ALSPAC young adults, 6.1% had persistent or recurrent depression, and childhood trauma/adversity was linked more strongly to this course than to transient depression (RRR 3.17).
- Why it matters: Limited evidence exists on how depression persists into young adulthood and whether early adversity and systemic inflammation explain that longer-lasting pattern.
- What they did: Depression status at ages 18, 24, and 30 was classified into never, transient, or persistent/recurrent ([≥]2 episodes) in 2,014 participants, while IL-6 and CRP were measured at ages 9, 16, 18, and 24. Multinomial logistic regression and causal mediation tested whether inflammatory markers mediated trauma effects.
- The result: Trauma/adversity showed a dose-response link to persistent/recurrent depression, with middle-to-late childhood (11–17 years) as a sensitive period (RRR 2.85), and it was associated with modestly higher IL-6 at age 24; CRP links and mediation by IL-6/CRP were not supported.
The findingWhy it mattersWhat they didThe result
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