The abstract is read at the publisher; the summary is JClub's.
Serum amyloid A (SAA) and C-reactive protein (CRP) measured from archived serum samples identify bacteriology-confirmed tuberculosis with AUCs of 0.961 and 0.953, respectively.
- Why it matters: High-burden TB programs need affordable, scalable, accessible screening tests that can triage symptomatic people effectively, addressing a gap in practical biomarker tools.
- What they did: In a cross-sectional diagnostic study of stored sera (confirmed TB n=57, probable TB n=56, healthy controls n=60), SAA and CRP were measured by near point-of-care fluorescence immunoassay, and IP-10 by ELISA.
- The result: SAA (cut-off >31.0 mg/L) reached 96.5% sensitivity and 88.6% specificity, CRP (cut-off 21.3 mg/L) reached 96.5% sensitivity and 86.0% specificity, and CRP+SAA gave 100.0% sensitivity and 83.3% specificity, while IP-10 performed poorly (AUC 0.545).
The findingWhy it mattersWhat they didThe result
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