The abstract is read at the publisher; the summary is JClub's.
In 830 adults with type 1 diabetes, 59 replicated circulating-protein signals predict diabetic kidney disease outcomes, including HAVCR1/KIM-1, GFRA1, CD14, and GDF15 forecasting albuminuria onset up to a decade earlier.
- Why it matters: Diabetic kidney disease is the leading cause of kidney failure, but the molecular events that start and drive progression are not well defined.
- What they did: Using longitudinal measurements of 5,420 circulating proteins over 10 years, the study tested associations with onset and progression while adjusting for established clinical risk factors, then replicated findings in an independent cohort.
- The result: Albuminuria onset is linked to HAVCR1/KIM-1, GFRA1, CD14, and GDF15; progression is linked to kidney–liver axis proteins (ASGR1, RBP4) and to immune and tumor necrosis factor receptor signaling, and Mendelian randomization prioritized UMOD, SORT1, CLSPN, MAST4, and EGF as potential targets.
The findingWhy it mattersWhat they didThe result
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