The abstract is read at the publisher; the summary is JClub's.
In a prospective cohort of 106 naturally cycling adults with DSM-5 ADHD, 54% showed robust, person-specific cyclical symptom change, with median 52% variance explained.
- Why it matters: Adults with ADHD often report menstrual-cycle worsening, but the field lacks prospective, person-level evidence for whether symptoms cycle reliably and whether effects reflect negative affect or pain.
- What they did: Participants rated daily inattention and hyperactivity-impulsivity (Barkley Adult ADHD Rating Scale-IV) alongside daily negative affect and pain, with salivary estradiol and progesterone for phase coding; generalized additive models tested sample and individual cycle curves.
- The result: Cyclic worsening most often peaked at and after menses rather than premenstrually, remained after adjusting for affect (68%) or pain (81%), and was not linked to PMDD or hormone differences.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.