Non-contact fingertip video to differentiate dengue haemorrhagic fever in plasma leakage from dengue fever: A prospective proof-of-concept cohort study

A non-contact ~30-second fingertip video distinguishes dengue haemorrhagic fever with plasma leakage from dengue fever, achieving AUC 0.963 in a held-out set of 50 recordings.

• Why it matters: Clinicians need to separate DHF from DF, but platelet count overlaps because thrombocytopenia is part of DHF criteria, limiting routine serial markers.
• What they did: In a prospective observational cohort at a national dengue referral centre, serial fingertip videos were recorded with contemporaneous clinical and haematological measurements, then classified in a held-out set.
• The result: Video probability separated groups with AUC 0.963 (95% CI 0.918–1.000), and in 49 recordings it reached AUC 0.961 versus 0.888 for platelet count, with exploratory evidence of added information beyond platelets.

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