Parent-of-Origin-Aware Genomic Analysis to Enhance Cascade Testing in Pancreatic Cancer: A Population-Based Study

Parent-of-Origin-Aware genomic analysis (POAga) determined parental origin for all variants in hereditary PDAC probands, and could immediately refine risk for at least 188 relatives.

• Why it matters: Cascade genetic testing is increasingly prioritized for pancreatic ductal adenocarcinoma, but family risk estimates can be limited when variant segregation by lineage is unclear.
• What they did: In one hundred consecutive hereditary PDAC probands (March 2014–December 2023), researchers measured cascade testing rates and offered POAga, which uses a new blood sample to assign maternal versus paternal origin.
• The result: Among 13 contacted and 9 who provided a research blood sample, POAga clarified which family side carried each variant, suggesting improved cascade testing effectiveness and prevention strategies.

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