CDC25B couples ribosome biogenesis to cell cycle kinetics to promote spinal cord neurogenesis

CDC25B overexpression in the chicken spinal cord increases ribosome biogenesis in neural progenitors, with RiBi rising in CDC25B-expressing neurogenic domains during normal development.

• Why it matters: Neural progenitors must coordinate cell cycle progression with molecular reprogramming during the proliferation-to-differentiation switch, but how CDC25B links these programs is unclear.
• What they did: Using gain-of-function CDC25B in chicken spinal cord and bulk RNA sequencing, the study measured ribosomal protein transcript upregulation and RiBi, then tracked mTORC1 activity and translation timing.
• The result: RiBi increases without a concurrent rise in translation; it precedes increased mTORC1 activity in neuronal precursors and later global translation in differentiating neurons, and mTORC1 activation can trigger premature differentiation.

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