Carrier-Limited Release Risk in Electrospun Nanofibers for Regenerative Endodontics: Constraint Discovery from 25 Formulations

PVP electrospun nanofiber mats for regenerative endodontics show a carrier-limited release risk, with PVP completing metronidazole/ciprofloxacin release within 8 h in cross-carrier evidence.

• Why it matters: Clinicians need intracanal disinfecting across a 1–4 week dressing interval without harming pulp-rebuilding stem cells, yet the campaign lacked direct release measurements.
• What they did: A 25-formulation electrospinning campaign of PVP fibers carrying metronidazole, ciprofloxacin, minocycline, and Ca(OH)2 was analyzed with machine learning, including logistic regression (96% leave-one-out) and diameter modeling (ridge MAE 193 nm, 95% CI 96 to 317 nm).
• The result: Cross-carrier evidence from 17 metronidazole/ciprofloxacin observations (two-sided censoring) found water-soluble carriers finished within 80 h (PVP within 8 h), while water-insoluble monolithic carriers did not reach 90% and released 1.5–50%.

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