Dengue Virus Serotype 2 Infection Transcriptionally Reprograms Host Neutrophils to Establish an Immunosuppressive Microenvironment in Mice

DV-2 infection in AG129 mice transcriptionally reprograms neutrophils, generating an immunosuppressive microenvironment linked to disease progression and FGL2-expressing Ly6Glow subsets.

• Why it matters: Innate immune cell transcriptomic changes during dengue progression are not fully defined, limiting understanding of how neutrophils contribute to immunosuppression and pathogenesis.
• What they did: Using scRNA profiling of bone marrow and spleen cells from DV-2-infected AG129 mice, the study mapped dynamic neutrophil signatures and identified FGL2-expressing Ly6Glow subpopulations appearing with progression.
• The result: Serum FGL2 was significantly elevated in DV-2-infected mice and dengue-positive patients, and splenocyte exposure to FGL2 or FGL2-enriched neutrophil secretomes suppressed T cell function and promoted an immunosuppressive phenotype.

AI summary of the abstract · may contain errors · not medical advice · read the paper.