Repetitive negative thinking is associated with amyloid accumulation over 3 years in cognitively healthy adults

Higher repetitive negative thinking in 94 cognitively healthy adults is linked to faster global cortical amyloid accumulation over 3 years (B=0.0120, P=0.012).

• Why it matters: Identifying modifiable psychological factors that track Alzheimer’s disease risk over time is a priority, and the psychological debt hypothesis predicts RNT could relate to AD biology.
• What they did: In the IMAP/IMAP+ longitudinal neuroimaging cohort, participants completed validated RNT, anxiety, and depression measures, while global amyloid (Florbetapir-PET), FDG-PET glucose metabolism, and MRI grey matter volume were modeled across up to 3 scans.
• The result: RNT predicted faster amyloid increases, including a tertile difference (P=0.008) and region-specific effects in early-vulnerable areas, while glucose metabolism and brain atrophy showed no association (Ps>0.05).

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