Aneuploidy profiling among different types of brain metastases reveals a colon cancer-specific chromosomal signature

Colorectal cancer brain metastases show a significantly higher degree of genomic instability than brain metastases from non-small cell lung, breast, and melanoma, with distinct aneuploidy arm patterns.

• Why it matters: Brain metastasis outcomes are poor, and it remains unclear whether genomic instability and aneuploidy differ by cancer type and metastatic organ site.
• What they did: The study profiled aneuploidy in brain metastases from non-small cell lung, breast, melanoma, and colorectal cancer, focusing on chromosomal arm imbalances with gains or losses.
• The result: Colorectal brain metastases had arm imbalance profiles with gains of 13q and 20q more frequent than other cancer types, and gains on chromosomes 7 and 16 were higher than in liver, lung, and lymph node metastases.

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