How Short Is Safe? Duration of Dual Antiplatelet Therapy Before Aspirin Withdrawal After Percutaneous Coronary Intervention: A Dose-Response Network Meta-Analysis

Aspirin withdrawal after PCI shows MI odds ratios linked to DAPT duration, with the MI OR dropping below 1.15 from about 90 days.

• Why it matters: Trials withdrew aspirin at fixed times, mostly versus 12-month DAPT, but syntheses disagreed on how short dual therapy can safely be.
• What they did: Bayesian network meta-analysis of 16 randomized trials (58,068 patients) modeled 12-month MI and major bleeding as functions of DAPT duration using Emax and spline, with a prespecified MI threshold of OR < 1.15.
• The result: MI ORs were 1.31 at 0 days, 1.17 at 30 days, and 1.09 at 90 days; bleeding decreased (OR 0.40 at 0 days, 0.62 at 90 days), and the MI threshold was met at 158 days (Emax) or 282 days (spline).

AI summary of the abstract · may contain errors · not medical advice · read the paper.