A connection-level genetic atlas of human cortical functional connectivity at rest and during a task

APOE ε4 is linked to lowered posterior default mode connectivity, and a cognition locus is linked to left posterior temporal (PHT) connections in UK Biobank European-ancestry participants.

• Why it matters: Prior genetic work on cortical functional connectivity aggregates traits, obscuring which specific connections variants influence across brain states.
• What they did: The study ran genome-wide association analyses on 64,620 connections among 360 cortical areas in UK Biobank at rest (n = 52,983) and during an emotion-processing task (n = 45,010), with replication (n = 15,546).
• The result: It found 247 resting and 96 task loci, with 112 resting loci replicated, and produced atlas summary statistics for every connection in both states.

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