Time to resolution of Long COVID symptoms and the associated factors among the people infected with SARS-CoV-2 during the 3rd wave of COVID-19 in Zambia: A prospective quantitative study

Vaccination status is significantly associated with faster symptom resolution for Long COVID in a cohort of 303 people infected with SARS-CoV-2 during Zambia’s 3rd wave, with aHR=1.71.

• Why it matters: Long COVID symptom persistence limits recovery, yet evidence on how quickly symptoms resolve and which factors matter is limited for people infected during Zambia’s 3rd wave.
• What they did: Over 24 months (September 2021–August 2023), investigators followed 303 randomly sampled participants from 7 healthcare facilities, using monthly clinical-record and interview data with Kaplan–Meier and Cox proportional hazards models.
• The result: Among 236 recovery events, median time to resolution was 6 (IQR: 5–8) months, and vaccination remained linked to time to resolution after adjustment (aHR=1.71, 95% CI: 1.02–2.86, p=0.04).

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