Inflammation reshapes epidermal and leukocyte differentiation resulting in altered glucocorticoid responsiveness

In zebrafish epidermal cells and macrophages during wounding-induced inflammation, dexamethasone responsiveness is reduced, while neutrophils retain glucocorticoid responsiveness.

• Why it matters: Glucocorticoids act broadly, but how inflammation reshapes cell type–specific GR signaling and differentiation is not well defined in vivo.
• What they did: Using single-cell RNA sequencing in zebrafish after wounding, the study mapped GR-mediated transcriptional regulation and linked dexamethasone responsiveness to transcriptional coregulator expression.
• The result: Inflammation-specific epidermal and macrophage subsets show elevated inflammatory markers and reduced GR transactivation, enabling candidate regulatory mechanisms for differential glucocorticoid responsiveness across cell types.

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