Multimodal Connectome Markers of Disruptive Behavior Problems in Youth: Distinct Patterns of Concurrent Severity and Prospective Symptom Change

Functional connectome connectivity in the ABCD Study predicts baseline disruptive behavior severity at ages 9–10 (ρ = 0.087) and 2-year symptom change (ρ = 0.038).

• Why it matters: Disruptive behavior problems are linked to altered emotion-regulation networks, but multimodal connectome markers for concurrent severity and later symptom change—especially by sex—are not well defined.
• What they did: In a sex-balanced ABCD sample, multimodal connectome-based predictive modeling used resting-state functional (n = 7,556) and structural (N = 8,978) connectivity, with covariate adjustment, permutation testing, and FDR correction.
• The result: Functional and structural connectomes predicted baseline severity (ρ = 0.087 and ρ = 0.071), while prospective functional prediction was significant (ρ = 0.038) and prospective structural prediction was mainly negative (ρ = 0.026), significant in males but not females.

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