A human induced pluripotent stem cell-based high-throughput screening platform for teratogenicity hazard identification

A human iPSC-based teratogenicity screening platform using four germ-layer models identifies 88% of known teratogens with 83% overall accuracy from 146 reference compounds.

• Why it matters: Teratogenic liability is often evaluated late with costly animal studies, risking program termination or limiting use for women of childbearing potential.
• What they did: The team built an automated, chemically defined, 384-well high-content imaging workflow across four hiPSC models and screened 146 compounds (90 teratogens, 56 non-teratogens).
• The result: The reported accuracy supports early hazard assessment and risk mitigation, enabling dose-response testing of hundreds of compounds and scaling to thousands per month.

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