Notch-independent Her6 contributes to control of neural stem cell maintenance by shifting Notch signaling from lateral inhibition towards lateral induction mode

Her6, a Notch-independent HES1 homolog in larval zebrafish brain, is pivotal for neural stem cell control, with G1 and G2 Notch activity linked to cell-cycle arrest programs.

• Why it matters: Stable neural proliferation zones require NSC maintenance alongside ongoing neurogenesis, but how Notch-dependent and Notch-independent transcription factors coordinate target expression remains unclear.
• What they did: The study combined genetic evidence with transcriptional network analysis to map how Her6 at G1 and Notch signaling at G2 regulate cell-cycle genes and modulate delta, jagged, lfng, and notch3 expression.
• The result: Her6 and Notch together differentially control Notch ligands and receptors, and spatial expression patterns support a shift toward Jagged-Notch3-mediated lateral induction in high her6 regions of larval and adult brain.

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