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Regulatory plasticity of the rdar biofilm morphotype in clinical uropathogenic Escherichia coli and its modulation by ciprofloxacin
bioRxiv · · Preprint · Open access
Mushtaq, Ali + 6 more
Abstract ↗AI summary
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Subinhibitory ciprofloxacin at 10 micrograms/mL suppresses rdar biofilm formation and surface colonization in ciprofloxacin-resistant clinical uropathogenic Escherichia coli isolates.
- Why it matters: The rdar morphotype is clinically relevant in urinary tract infections, but how it varies in patients and how antibiotics modulate it is unclear.
- What they did: Among 146 Lahore, Pakistan UTI isolates (2017–2019), rdar-like colonies occurred in 36.3% at 28 degrees C and 29.5% at 37 degrees C; in ciprofloxacin-resistant isolates (MIC at least 128 micrograms/mL), 10 micrograms/mL ciprofloxacin was tested for effects on rdar expression and biofilm structure.
- The result: Ciprofloxacin disrupted extracellular matrix architecture and abolished glass surface colonization, indicating antibiotic-mediated suppression of the rdar phenotype in these resistant isolates.
The findingWhy it mattersWhat they didThe result
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