bioRxivJClub
Altered neurodevelopment, CSF volume, and emotional reactivity following postnatal Zika virus infection in infant macaques
bioRxiv · · Preprint · Open access
Desai, Love + 19 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Postnatal Zika virus infection in 1-month-old rhesus macaque infants is linked to larger total CSF volume at 3 months and sex-specific brain structural changes.
- Why it matters: The neurodevelopmental effects of postnatal ZIKV infection are understudied compared with congenital Zika syndrome, leaving uncertainty about brain and behavioral risks after exposure.
- What they did: Male and female infant rhesus macaques infected with ZIKV at 1 month were compared with sex-, age-, and rearing-matched uninfected controls and Poly-IC–treated innate immune controls, with behavioral testing and MRI at 3 months.
- The result: ZIKV-infected infants showed poor early state control and increased hostility during an acute stressor, plus sex-specific caregiver-separation behavior changes; MRI revealed reduced visual processing region volumes and sex-specific structural alterations.
The findingWhy it mattersWhat they didThe result
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