mRNArchitect: sequence design of mRNA medicines

mRNArchitect improves primary mRNA sequence design by optimizing codon usage, secondary structure, and manufacturability, yielding experimentally validated gains in expression, stability, and immunogenicity.

• Why it matters: mRNA medicines depend on sequence-level choices, but existing design methods may not jointly optimize translation, stability, and immune activation for different therapeutic contexts.
• What they did: The toolkit applies multiple optimization strategies for short versus long expression profiles and supports clinical use cases like vaccines and cell or gene therapies, using a catalogue of validated RNA elements.
• The result: Experimental validation across multiple cell types and tissues shows mRNArchitect designs improve expression, stability, and immunogenicity compared with current design methods, enabling more programmable, cell-type-specific control.

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