Conserved Laminar-Cellular Architecture Predicts the Spectrolaminar Motif

In macaque cortex, the spectrolaminar motif of layer-resolved LFP power is predictable from conserved laminar cellular gradients, with highly conserved structure-to-function regression coefficients across 11 brain areas.

• Why it matters: The key gap is which cytoarchitectonic features explain the spectrolaminar motif, and whether a single cellular-to-spectral rule can generalize across cortex and into disease.
• What they did: Across 11 macaque cortical areas, histology and neurophysiology related laminar distributions of parvalbumin, calbindin, calretinin interneurons and pyramidal neurons to laminar LFP power, using low-dimensional two-component patterns and regression mapping.
• The result: The model predicted spectrolaminar alterations from post-mortem cytoarchitectonic changes in schizophrenia, aligning with known non-invasive neurophysiology and enabling a predictive structure-function framework.

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