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Demethylzeylasteral is identified as a direct interactor of ACLY from a screen of 50 structurally diverse natural products using thermal proteomics plus HoloGNN.
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Natural Compounds in Disease Treatment
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Inhibiting p65 autopalmitoylation with licochalcone D reduces NF-κB activity by blocking its nuclear localization and complex formation.
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Minoxidil hydrochloride inhibits NLRP3 inflammasome activation in J774A.1 cells, reducing IL-1beta and IL-18 release with IC50 values of 1.2 and 1.06 micron M.
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Topics moving, week to 3 Nov 2026
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