Eosinophilic Esophagitis
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Eosinophilic gastritis affects the stomach with dense eosinophilic infiltration and lacks approved long-term treatments, highlighting a significant unmet medical need.
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BHLHE40 orchestrates intestinal immunity by regulating ILC3s and RORγt⁺ APCs, crucial for mucosal defense and tolerance, with a 40-fold increase in expression during inflammation.
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Targeted exclusion diets based on confocal laser endomicroscopy do not significantly improve irritable bowel syndrome symptoms, with response rates of 42% versus 36%.
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