Research area · week to 3 Oct 2026

Mycobacterium research and diagnosis

Moving in bioRxiv, medRxiv, Applied and environmental microbiology, mSystems, eLife, Genome Medicine, Immunity, Nature Microbiology.

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Polyketide synthase 12 is an in vivo essential source of novel mycolyl lipids in Mycobacterium tuberculosis
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.25.754250
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Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach.
eLife · 23 Sept 2026 · Journal Article
Semapimod inhibits L-leucine uptake in Mycobacterium tuberculosis, reducing bacterial load in infected mice despite no in vitro efficacy.
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https://jclub.com.au/a/42775406
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Gene conversion is a key driver of diversity hotspots in M. tuberculosis antigens and virulence-associated loci
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.26.708061
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Tobramycin enhances Mycobacterium abscessus fitness through whiB7 induction.
Proceedings of the National Academy of Sciences · 22 Sept 2026 · Journal Article
Tobramycin increases Mycobacterium abscessus survival by inducing whiB7, promoting persistent infection in cystic fibrosis airway conditions.
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https://jclub.com.au/a/42752235
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Migration and tuberculosis transmission in Hamburg, Germany: insights from 25 years of molecular epidemiology.
Genome Medicine · 17 Sept 2026 · Journal Article
Migration increased genetic diversity of Mycobacterium tuberculosis in Hamburg but did not significantly change local transmission patterns, which remained lineage-specific.
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https://jclub.com.au/a/42768361
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Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.26.678883
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β-Lactam antibiotics trigger mouse TLR2/4- and human TLR2/5-dependent Jarisch-Herxheimer reaction in leptospirosis
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.29.721589
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A state-structured pharmacodynamic framework separating resistance, tolerance and persistence, applied to Mycobacterium tuberculosis and Staphylococcus aureus
bioRxiv · 8 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.02.12.637810
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Transition of Staphylococcus aureus tetracycline resistance plasmid pT181 from independent multicopy replicon to predominantly integrated chromosomal element over 65 years
bioRxiv · 5 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.14.675889
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Autodissemination stations suppress Aedes notoscriptus mosquitoes and reduce Buruli ulcer risk in urban Australia: a randomized controlled field trial.
Nature Microbiology · 1 Sept 2026 · Randomized Controlled Trial
Autodissemination stations reduce Aedes notoscriptus mosquito populations by 70% and lower Buruli ulcer cases by 83% in urban Melbourne, Australia.
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https://jclub.com.au/a/42661072
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Effects of oral hygiene and food intake on tongue swab testing for tuberculosis in South Africa
medRxiv · 22 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.19.26360845
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Leucine auxotrophic marker for genetic manipulation of Mycobacterium abscessus.
Applied and environmental microbiology · 19 Aug 2026 · Journal Article
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https://jclub.com.au/a/42461037
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Disinfection and damage of nontuberculous mycobacteria by different UV wavelengths.
Applied and environmental microbiology · 19 Aug 2026 · Journal Article
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https://jclub.com.au/a/42535850
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Molecular surveillance of multidrug-resistant tuberculosis at the dawn of the genomic era, Argentina, 2013-2022
medRxiv · 18 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.27.26344616
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Temperature and pH growth preferences predict the pathogenicity and environmental distributions of nontuberculous mycobacteria.
mSystems · 18 Aug 2026 · Journal Article
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https://jclub.com.au/a/42478856
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Population-level genome sequencing reveals distinct Mycobacterium tuberculosis intrahost mutational trajectories in simian immunodeficiency virus-coinfected and antiretroviral treated non-human primates.
mSystems · 18 Aug 2026 · Journal Article
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https://jclub.com.au/a/42505123
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Ethambutol resistance preceding macrolide resistance in Mycobacterium avium complex pulmonary disease: a retrospective longitudinal study and in vitro analysis
medRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.12.26360314
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Monocytic niches escape T cell surveillance and promote Mycobacterium tuberculosis persistence in lymph nodes.
Immunity · 11 Aug 2026 · Journal Article
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https://jclub.com.au/a/42335893
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Type I interferon responses contribute to immune protection against mycobacterial infection
medRxiv · 10 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.06.26.24309490
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