Serum lithium, nickel, cobalt, and manganese are linked to a 56.3% greater risk of chronic kidney disease in Chinese older adults, with lithium contributing most strongly.
Heavy Metal Exposure and Toxicity
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Prenatal arsenic exposure from metal mixtures significantly increases offspring blood pressure, with a 4.41 mm Hg rise in systolic BP linked to maternal levels.
Co-exposure to environmental lead and hypertension significantly worsens anxiety and depression in mice, with a 2.5-fold increase in behavioral deficits compared to single exposures.
A single prenatal urinary arsenic measurement poorly predicts arsenic profiles and growth outcomes in children aged 3-5 years in a high seafood-consuming population.
Intracellular zinc directly inhibits the sperm-specific Slo3 potassium channel by up to micromolar concentrations, with slow dissociation dynamics, affecting sperm capacitation.
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Seasonal multi-matrix assessment reveals pesticide and metal bioaccumulation peaks in Lake Chapala, Mexico, with ecological risk reaching 935.9 during the rainy season.
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