Host N-glycosylation is essential for E. coli infection, facilitating adhesion and secretion system activity through two distinct pathways.
- Open access
Glycosylation and Glycoproteins Research
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Latest in Glycosylation and Glycoproteins Research
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Galectin-1 drives monocyte hyperinflammation in myeloproliferative neoplasms, with Lgals1 ablation reducing disease features in mice.
- Open access
A novel Fab-dimerized glycan (FDG) antibody with a dual-glycan clamp epitope was isolated, showing approximately 30% breadth against HIV-1 and unique architecture.
- Open access
Pathogenic O-GlcNAc dyshomeostasis linked to neurodevelopmental defects and behavioral abnormalities in a rodent model of OGT-ID.
- Open access
- 1 cites
Plant-derived pectin forms distinct nanoscale morphologies and tightly associates with animal tissue, demonstrating potential as a bioadhesive in lung surgery.
- Open access
NDST2-driven N-glycosylation of EGFR at four conserved sites promotes lenvatinib resistance in hepatocellular carcinoma, with NDST2 upregulation correlating with resistance.
Folding-mediated secretion using ProAla mutations yields highly pure bispecific antibodies with 100% correct pairing in IgG-like formats.
- Open access
- 1 cites
GlycoRNA biogenesis is significantly impaired in human MASLD livers, with most glycoRNAs reduced by approximately 50%, contributing to disease progression.
- 1 cites
Large-scale glycomics datasets are revolutionizing understanding of glycan functions, with recent advances enabling extensive studies to uncover biological roles.
Galectin-3 enhances CaV1.2 channel activity and blood pressure, with blocking peptides reducing hypertension by over 35% in rat models.
Cis glycan-glycan interactions form transient homodimers that organize membrane nanodomains and regulate receptor signaling, with 39 ganglioside analogs demonstrating this in living cells.
- Open access
A high-throughput, user-friendly mucus microrheology platform measures small sample rheology with 3-10 μL volumes, enabling rapid assessment of mucus properties in respiratory diseases.
- Open access
- 2 cites
Lanthivirin BGCs in Actinobacteria produce lanthipeptides that provide potent anti-phage activity, with 6 distinct systems confirmed to inhibit phage DNA replication.
- Open access
- 11 cites
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