An enzyme-responsive nanoplatform enhances cancer immunotherapy by rewiring host-microbe tryptophan metabolism, boosting antitumor immunity with 92% tumor reduction in mice.
Cell Host & Microbe
Cell Press · Microbiology & Mycology · ISSN 1931-3128, 1934-6069
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Elevated MIPS expression in wheat and maize confers up to 88% reduction in DON accumulation and rescues 43% yield loss, providing broad resistance to Fusarium diseases.
A bacterial exopolysaccharide containing phosphocholine from Clostridium immunis prevents obesity by modulating immune signals in mice.
Dietary pectin triggers a microbiota-dependent high-IgA response in mice by remodeling bacterial surfaces with glycosphingolipids, notably HexCer (34:0).
Gabija inhibits phage circularization and DNA replication by targeting linear DNA lacking RecBCD activity, reducing phage proliferation in Pseudomonas aeruginosa.
Defined human Clostridia consortia effectively reverse colitis in mice through mechanisms involving bacterial tryptophan metabolites, independent of SCFAs and IL-10.
Bacterial endosymbionts within Fusarium oxysporum increase fungal virulence by disrupting the rhizosphere microbiome, reducing disease-suppressive bacteria by up to 50%.
Mouth-to-gut microbial transmission signatures enable accurate, non-invasive diagnosis of gastrointestinal cancers with over 90% sensitivity across multiple cohorts.
Strong, sustained type I IFN signaling intrinsically impairs IFNγ responses in macrophages, increasing susceptibility to tuberculosis in Mycobacterium tuberculosis infection.
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Cell-type-specific immune responses in Arabidopsis restrict pathogen invasion despite uniform effector-triggered immunity activation.
Diet-microbe interactions, rather than obesity alone, enhance immunotherapy responses in mouse models, revealing a surprising benefit of obesity-related factors.
Lactobacillus gasseri and its exopolysaccharide reduce endometrial aging and enhance implantation in aged mice, suggesting potential to reverse reproductive decline.
Lactobacillus gasseri postbiotics improve endometrial receptivity and implantation in aged models, counteracting age-related fertility decline with a 40% enhancement in mice.
Host eicosanoid signals from LTA4H regulate a specialized granuloma fibroblast population critical for containing mycobacterial infection, with a distinct role across TB granulomas.
Endobacteria within fungi alter fungal behavior, influencing plant disease outcomes by antagonizing beneficial soil microbes.
Type I interferons and interferon-γ antagonism critically influence susceptibility to Mycobacterium tuberculosis infection.
Fibroblasts at the granuloma periphery, regulated by LTA4H, limit mycobacterial spread and influence tuberculosis severity.
Microbial metabolite indole-3-acetamide reduces PCOS symptoms by activating HIF-2α-ceramide signaling, with a 50% improvement observed in mouse models.
Bacterial membrane-hybridized oral nanovaccines activate mucosal and systemic immune responses, achieving tumor control and memory formation in cancer models.
Oral bacteria transmission to the gut increases in gastrointestinal cancers and can be detected through saliva, providing a potential diagnostic marker.
Gut-derived pantothenic acid from Bacteroides fragilis improves metabolic syndrome by restoring gut barrier function and reducing inflammation.
Advances in vaccines, antibodies, and antivirals offer hope for combating hantavirus infections, which currently lack approved medical countermeasures.
The rice circadian clock component Nhd1 synchronizes rhizosphere microbial activity with plant nitrogen demand, enhancing nitrogen use efficiency by up to 40%.
Corynebacterium glucuronolyticum-like bacteria promote calcium oxalate kidney stone formation by degrading hippuric acid and enhancing crystal aggregation, with evidence from experimental models.
Streptococcus anginosus promotes gastric cancer progression and immune evasion through a chromatin remodeler-mediated epigenetic reprogramming, with 50% of tumors enriched in this bacterium.
Bacteroides acidifaciens enrichment driven by KRAS mutation promotes colorectal tumorigenesis, correlating with poor prognosis in KRAS-mutant CRC patients.
Dual sensing activates bacterial antiviral reverse transcriptase, leading to membrane targeting and growth arrest, with 2 distinct mechanisms identified.
Mobile virus-derived siRNAs induce repeated 3-4 cell immunization events that effectively contain plant viruses, as shown in Arabidopsis roots infected with turnip yellows virus.
A bacterial effector, FadA, modifies host mRNA through oxidative damage, increasing oxo 8 G modifications and promoting Legionella pneumophila virulence.
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