A spatial atlas of muscle-invasive bladder cancer uncovers lineage-specific vulnerabilities and immune structures across 22 tumors.
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[18F]RCCB6 PET/CT detects ccRCC metastases with 94.2% sensitivity, outperforming [18F]FDG PET/CT and conventional imaging in accuracy and specificity.
Metastasis-to-metastasis seeding dominates bladder cancer spread, with heterogeneity and early driver alterations linked to poor prognosis in specific subtypes.
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HSPA6 promotes lenvatinib resistance in hepatocellular carcinoma by stabilizing TXNRD1 through phase separation, reducing ferroptosis, and correlating with poor patient outcomes.
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