Five-year survival rates with neoadjuvant immune checkpoint inhibitors reach up to 87.5% in melanoma, significantly outperforming targeted therapies and combination regimens.
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Cutaneous Melanoma Detection and Management
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Ultrasound radiomics combined with an immune-related gene signature predicts melanoma response to immune checkpoint inhibitors with 78-88% accuracy.
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Cost-Aware EfficientNet (CAEN) achieves up to 87% recall in skin lesion classification across diverse skin tones, reducing bias in dermatological AI by 16.75% over previous models.
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Spatial analysis uncovers that melanoma transition involves a 3-fold increase in proliferation, metabolic changes, and microenvironment remodeling in nevus-associated melanomas.
RMC-7977 and daraxonrasib show potent activity against NRAS-mutated melanoma but face resistance mechanisms involving Ppia and Map2k1 mutations.
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Melanoma exosomal hsa-miR-221-5p suppresses keratinocyte LL-37, promoting tumor progression by impairing immune defenses and enhancing invasion.
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