Obinutuzumab significantly improves disease activity in adults with active systemic lupus erythematosus, achieving a 23.1 percentage point higher response rate than placebo at week 52.
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Metabolic reprogramming in lymphocytes, including increased glycolysis and mitochondrial dysfunction, drives T-cell-mediated autoimmunity in diseases like MS, RA, and T1D.
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Single-cell genomics reveals diverse pathogenic immune cell subsets in rheumatoid arthritis, paving the way for targeted therapies.
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