Research area · week to 3 Oct 2026

Neuroscience and Neuropharmacology Research

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Neuronal ensembles in visual cortex reactivate during hypnagogic sleep onset
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2023.04.26.538480
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The lipidomic architecture of the mouse brain.
Nature · 1 Oct 2026 · Journal Article
Mapping the mouse brain lipidome reveals a detailed biochemical architecture with significant spatial heterogeneity across regions and conditions.
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https://jclub.com.au/a/42778605
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A cortical-hippocampal communication undergoes rebalancing after new learning.
eLife · 1 Oct 2026 · Journal Article
Reorganization of anterior cingulate cortex-CA1 communication after learning selectively suppresses superficial CA1 neurons, aiding memory consolidation.
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https://jclub.com.au/a/42821316
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Human neurons undergo protracted functional maturation into adulthood
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.01.668139
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A pathogenic AMPAR mutation disrupts hippocampal synapse maturation and homeostasis
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.26.701845
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Prion Protein Deficiency Results in Synaptic, Neural Network and Behavioral Alterations
bioRxiv · 29 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.07.716931
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Conserved neural dynamics of anesthesia and the oblivion of species.
Nature Neuroscience · 29 Sept 2026 · Journal Article
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https://jclub.com.au/a/42811120
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Comprehensive profiling of brain dynamics during anesthesia across phylogeny.
Nature Neuroscience · 29 Sept 2026 · Journal Article
Anesthesia induces a conserved neural state across species, characterized by shorter timescales and reduced inter-regional synchrony, observed in humans, primates, rodents, fish, and nematodes.
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https://jclub.com.au/a/42811119
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PKD2L1 channels segregated to the apical compartment are the dual-mode pH sensor in cerebrospinal fluid-contacting neurons.
eLife · 29 Sept 2026 · Journal Article
PKD2L1 channels in cerebrospinal fluid-contacting neurons act as dual-mode pH sensors, with high sensitivity around physiological pH levels.
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https://jclub.com.au/a/42809452
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An electrical brain network encodes anxiety in health and depressive states
bioRxiv · 28 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.06.26.600900
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Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons.
eLife · 28 Sept 2026 · Journal Article
Hyperphosphorylated tau disrupts microtubule envelopes and impairs lysosome transport, contributing to neurodegeneration in tauopathies like Alzheimer's disease.
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https://jclub.com.au/a/42804373
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D-serine suppresses one-carbon metabolism by competing with mitochondrial L-serine transport
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.09.03.610855
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Synaptic GABA dysfunction of thalamocortical neurons impairs sleep spindle morphology and fear extinction.
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.28.728431
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Mitochondria remodel near synapses to boost metabolic capacity and fuel plasticity
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.27.672715
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Presynaptic GABABSignaling Enhances Synaptic Inhibition Without Mitigating Persistent Dentate Gyrus Hyperexcitability After Status Epilepticus
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.752988
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How sparse can a fly-brain model be? Connection strength, wiring placement, network state and task jointly determine function-preserving compression of the Drosophila connectome
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.19.752860
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Mouse Neural Organoids Model the Mature In Vivo Synaptic Proteome
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.753785
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Abstract representation in the hippocampus predicts spontaneously adopted structure-based behavioral strategy
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.752934
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Direct voltage imaging of peripheral axons in vivo reveals ongoing nociceptor firing in healthy mice
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.19.752889
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Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep.
eLife · 23 Sept 2026 · Journal Article
Disrupting activity in a specific subset of dopaminergic neurons during memory consolidation impairs long-term memory by causing sleep fragmentation in Drosophila melanogaster.
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https://jclub.com.au/a/42775636
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GABAergic interneuron pathology in schizophrenia: a systematic review and meta-analysis across cell-types, brain areas, and cortical layers
bioRxiv · 18 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.23.655812
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Ventral Striatal Dopamine Increases following Hippocampal Sharp-Wave Ripples
bioRxiv · 18 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.24.666687
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Open- and Closed-Loop Microcomplexes in Neocerebellum
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.17.706406
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A Muller glia-retinal pigment epithelium apical network surrounding cone outer segments in fish and mouse
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.23.719722
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Levetiracetam therapeutically targets GABAergic synapses in diffuse midline glioma.
Nature Medicine · 17 Sept 2026 · Journal Article
Levetiracetam extends survival in children with diffuse midline glioma by targeting GABAergic synapses, but not in other glioma subtypes.
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https://jclub.com.au/a/42754728
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Phosphoproteome modifications and cortical circuit dysfunction are linked to the early-stage progression of alpha-synuclein aggregation.
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.01.24.634820
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Hippocampal astrocytic sequences emerge during learning and memory recall.
Nature Neuroscience · 16 Sept 2026 · Journal Article
Hippocampal astrocytes generate time-compressed calcium sequences during learning and recall, resembling neuronal time-cell activity, in the dorsal CA1 region of mice.
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https://jclub.com.au/a/42749824
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A retinoic acid autoregulatory loop governing prefrontal-motor arealization.
Nature · 16 Sept 2026 · Journal Article
A conserved autoregulatory loop involving retinoic acid and MEIS2 directs prefrontal-motor cortical arealization in humans and mice.
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https://jclub.com.au/a/42749810
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Silencing basal forebrain cholinergic input to the infralimbic cortex renders fear extinction resistant to renewal
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.06.736678
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Anesthesia unconsciousness recruits dynamic parabrachial activity within a distributed brain-wide ensemble
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.03.28.646066
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