The many facets of human brain asymmetry.

Brain left-right asymmetry is an organizing principle of human brain function, and recent multi-scale evidence shows its facets vary largely independently across individuals.

• Why it matters: Prior work lacked an integrated view linking imaging, cellular, and molecular findings, and it was unclear whether asymmetry reflects one trait or multiple separable components.
• What they did: This Review synthesizes advances in neuroimage analysis, genomics, and large-scale data to connect functional, macro-anatomical, microstructural, cellular, and molecular asymmetries.
• The result: The synthesis supports a multivariate, multi-level model in which inter-individual variation, atypical forms, developmental origins, lifespan trajectories, genetic architecture, and disorder relevance can be examined across distinct asymmetry aspects.

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