Efficient catalyst-controlled C-H arylation of arenes.

Nature · 11 Nov 2026 · Journal Article

Zhang, González-Fernández + more

The abstract is read at the publisher; the summary is JClub's.

A palladium(II) dicarboxylate catalyst microenvironment enables high-selectivity C-H arylation at sterically exposed sites, including successive arylations of benzene.

Why it matters: Direct C-H arylation avoids preinstalled handles, but general catalysts that maintain high yields across arene classes while controlling where arylation occurs remain challenging.
What they did: The authors use an advanced palladium(II) precatalyst with tailored diaryliodonium reagents to transfer aryl groups under mild conditions, targeting sterically exposed C-H sites.
The result: The method works across electron-rich to electron-deficient arenes and performs late-stage C-H arylation, installing aryl groups bearing triflates, iodides, boronate esters, or N-hydroxysuccinimide esters.

AI summary of the abstract · may contain errors · not medical advice · read the paper.

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Equimolar cross-coupling of arenes and azoles by alternating current electrolysis.
Nature Communications · 16 Oct 2026 · Journal Article
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Alternating current electrolysis enables equimolar cross-coupling of arenes and azoles, including unprecedented benzene reactivity, reaching macromolecules up to 910 molecular weight.
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Enantioselective palladium-catalyzed carbonylation of gem-dibromoalkenes to chiral benzo[7]annulenes.
Nature Communications · 3 Oct 2026 · Journal Article
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A palladium-catalyzed asymmetric monocarbonylation of benzo[7]annulene-based gem-dibromoalkenes yields inherently chiral tetrasubstituted benzo[7]annulene derivatives with up to 97% yield and up to 98:2 er.
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https://jclub.com.au/a/42967917
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Dialkyl ether synthesis through heteroatom homolytic substitution.
Nature · 1 Oct 2026 · Journal Article
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A titanium/visible-light photoredox platform enables radical het-S H 2 coupling of carboxylic-acid-derived redox-active esters with alcohols to synthesize sterically hindered dialkyl ethers across 3°-2°, 3°-1°, 2°-2°, and 2°-1° patterns.
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Efficient catalyst-controlled C-H arylation of arenes.

Related in JClub

Equimolar cross-coupling of arenes and azoles by alternating current electrolysis.

Enantioselective palladium-catalyzed carbonylation of gem-dibromoalkenes to chiral benzo[7]annulenes.

Dialkyl ether synthesis through heteroatom homolytic substitution.

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