The cortico-basal ganglia-thalamic network: a connectomic framework.

A connectomic synthesis defines a multiscale cortico-basal ganglia-thalamic network framework with modular organization, graded boundaries, and re-entrant interactions across cortical, basal ganglia, and thalamic nodes.

• Why it matters: Classical CBGT work established topographic, specialized circuits, but newer connectomics are needed to resolve how parallel streams converge and interact across spatial and cellular scales.
• What they did: The study synthesizes recent mesoscale and single-neuron connectomic findings, integrating structural network features with molecular, transcriptomic, and neuronal morphological datasets.
• The result: The resulting structural framework preserves functional specialization while enabling cross-domain integration, supporting testable hypotheses linking circuit architecture to computation, behavior, and dysfunction in neurological and psychiatric disorders.

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